Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells.

Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells.

Huachansu, a traditional Chinese medicine prepared from the dried toad skin, has been used in clinical studies for various cancers in China. Resibufogenin is a component of huachansu and classified as bufadienolides. Resibufogenin has been shown to exhibit the anti-proliferative effect against cance...

Full description

Bibliographic Details
Main Authors:	Masami Ichikawa, Yoshihiro Sowa, Yosuke Iizumi, Yuichi Aono, Toshiyuki Sakai
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4488249?pdf=render

Similar Items

The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9.
by: Yosuke Iizumi, et al.
Published: (2013-01-01)

Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells
by: Ning Wang, et al.
Published: (2016-11-01)

Smenospongine, a Sesquiterpene Aminoquinone from a Marine Sponge, Induces G1 Arrest or Apoptosis in Different Leukemia Cells
by: Motomasa Kobayashi, et al.
Published: (2008-08-01)

Ethanol extracts from the branch of Taxillus yadoriki parasitic to Neolitsea sericea induces cyclin D1 proteasomal degradation through cyclin D1 nuclear export
by: Su Bin Park, et al.
Published: (2018-06-01)

Resibufogenin and cinobufagin activate central neurons through an ouabain-like action.
by: Ze-Jun Wang, et al.
Published: (2014-01-01)

Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.
by: Ryoichi Tanaka, et al.
Published: (2015-01-01)

ATP depletion during mitotic arrest induces mitotic slippage and APC/CCdh1-dependent cyclin B1 degradation
by: Yun Yeon Park, et al.
Published: (2018-04-01)

Resibufogenin inhibits the growth of human osteosarcoma MG-63 cells via mitochondrial pathway
by: Yue Zhang, et al.
Published: (2014-09-01)

Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis
by: Qinrui Han, et al.
Published: (2018-07-01)

Human Immunodeficiency Virus Type 1 Vif causes dysfunction of Cdk1 and CyclinB1: implications for cell cycle arrest
by: Chaigne-Delalande Benjamin, et al.
Published: (2011-05-01)

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells
by: Ha Na Kim, et al.
Published: (2019-02-01)

Cyclin B1 overexpression induces cell death independent of mitotic arrest.
by: Joshua M Eichhorn, et al.
Published: (2014-01-01)

Autophagy-reugulated ubiquitination and proteasomal degradation of ULK1
by: Liang-Yu Pang, et al.
Published: (2014)

NQO1 inhibits proteasome-mediated degradation of HIF-1α
by: Eun-Taex Oh, et al.
Published: (2016-12-01)

Resibufogenin Suppresses Triple-Negative Breast Cancer Angiogenesis by Blocking VEGFR2-Mediated Signaling Pathway
by: Ting Yang, et al.
Published: (2021-04-01)

Correction: cyclin b1 overexpression induces cell death independent of mitotic arrest.
Published: (2015-01-01)

CMIP interacts with WT1 and targets it on the proteasome degradation pathway
by: Shao‐Yu Zhang, et al.
Published: (2021-07-01)

JMJD5 links CRY1 function and proteasomal degradation.
by: Anand R Saran, et al.
Published: (2018-11-01)

Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins
by: Sneh Lata, et al.
Published: (2018-11-01)

Anticancer activity of calyx of Diospyros kaki Thunb. through downregulation of cyclin D1 via inducing proteasomal degradation and transcriptional inhibition in human colorectal cancer cells
by: Su Bin Park, et al.
Published: (2017-09-01)

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
by: Tobias Jung, et al.
Published: (2014-01-01)

Analysis of Resibufogenin on Cardiac conduction reveals a species difference in the cardiac electrophysiology: Rats versus guinea pigs.
by: Tao Song, et al.
Published: (2021-07-01)

SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1
by: Zheng Bin, et al.
Published: (2020-06-01)

Proteasome inhibition in lymphoid malignancy
by: Strauss, Sandra Jean
Published: (2006)

The role of the proteasome in haematopoietic malignancy
by: Magill, E. L.
Published: (2003)

The Discodermia calyx Toxin Calyculin A Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells
by: David L. Brautigan, et al.
Published: (2011-01-01)

Autophagy regulates tumorigenesis through selective degradation of cyclin D1
by: Shan-YingWu, et al.
Published: (2014)

ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability
by: Zhi-Hong Chen, et al.
Published: (2019-07-01)

Correction: JMJD5 links CRY1 function and proteasomal degradation.
by: Anand R Saran, et al.
Published: (2019-08-01)

Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence
by: Li Bin, et al.
Published: (2012-07-01)

Promising galactose-decorated biodegradable poloxamer 188-PLGA diblock copolymer nanoparticles of resibufogenin for enhancing liver cancer therapy
by: Hao Dong, et al.
Published: (2017-01-01)

The role of p53 in the regulation of Cdc2 and cyclin B1 in radiation-induced G2 arrest in human cells
by: Winters, Zoe Ellen
Published: (1999)

The proteasome and the degradation of oxidized proteins: Part I—structure of proteasomes
by: Tobias Jung, et al.
Published: (2013-01-01)

Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast.
by: Joan M Martínez-Láinez, et al.
Published: (2018-08-01)

SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.
by: Yaju Wang, et al.
Published: (2012-01-01)

Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest
by: Jae-Sun Choi, et al.
Published: (2018-09-01)

Proteasome Inhibition Suppresses KIT-Independent Gastrointestinal Stromal Tumors Via Targeting Hippo/YAP/Cyclin D1 Signaling
by: Ting Chen, et al.
Published: (2021-05-01)

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
by: Swarna L. Vijayaraj, et al.
Published: (2021-05-01)

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.
by: Hanneke Hoelen, et al.
Published: (2015-01-01)

The N-Terminal Domain of Y-Box Binding Protein-1 Induces Cell Cycle Arrest in G2/M Phase by Binding to Cyclin D1
by: Payal Khandelwal, et al.
Published: (2009-01-01)