Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells

Normally, cell proliferation and death are carefully balanced in higher eukaryotes, but one of the most important regulatory mechanisms, apoptosis, is upset in many malignancies, including hepatocellular-derived ones. Therefore, reinforcing cell death often is mandatory in anticancer therapy. We pre...

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Bibliographic Details
Main Authors: Chiara Ullio, Josefina Casas, Ulf T. Brunk, Giuseppina Sala, Gemma Fabriàs, Riccardo Ghidoni, Gabriella Bonelli, Francesco M. Baccino, Riccardo Autelli
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Journal of Lipid Research
Subjects:
ceramide
hepatocellular carcinoma
lysosomes
sphingolipids
tumor necrosis factor-α
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317065

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