Development of a Rapid-Onset, Acid-Labile Linkage Polyplex-Mixed Micellar System for Anticancer Therapy

Development of a Rapid-Onset, Acid-Labile Linkage Polyplex-Mixed Micellar System for Anticancer Therapy

In the treatment of cancers, small interfering ribonucleic acids (siRNAs) are delivered into cells to inhibit the oncogenic protein’s expression; however, polyanions, hydrophilicity, and rapid degradations in blood, endosomal or secondary lysosomal degradation hamper clinal applications. In this stu...

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Bibliographic Details
Main Authors: Shiou-Fen Hung, Yu-Han Wen, Lu-Yi Yu, Hsin-Cheng Chiu, Yi-Ting Chiang, Chun-Liang Lo
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Polymers
Subjects:
siRNA delivery
acid-labile
mixed micelle
anticancer therapy
Online Access:https://www.mdpi.com/2073-4360/13/11/1823

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