High Resolution Computed Tomography in Asthma

• Main Authors: Nabil Maradny, Tariq Sinan, Omolara Roberts, Abdulaziz Muquim, Jayakrishnan B, Mousa Khadadah, Ibrahim Lasheen
• Format: Article
• Language: English
• Published: Oman Medical Specialty Board 2012-03-01
• Series: Oman Medical Journal
• Subjects: Asthma; computed tomography; HRCT; pulmonary function; air trapping; Bronchiectasis
• Online Access: http://journals.indexcopernicus.com/fulltxt.php?ICID=989901
• ISSN: 1999-768X; 2070-5204

 Objectives: High-resolution computed tomography (HRCT) can detect the structural abnormalities in asthma. This study attempts to correlate these abnormalities with clinical and pulmonary function test (PFT) data.Methods: Consecutive stable asthma patients attending Mubarak Al Kabeer Hospital, Kuwait, were subjected to HRCT during a six month period from July 2004 to December 2004, after initial evaluation and PFT.Results: Of the 28 cases, sixteen (57.1�20had moderate, 6 (21.4�20had mild and 6 (21.4�20had severe persistent asthma. Thirteen (46.4�20patients had asthma for 1 to 5 years and 12 (42.9�20were having asthma for >10 years. Bronchial wall thickening (57.1� bronchiectasis (28.6� mucoid impaction (17.9� mosaic attenuation (10.7� air trapping (78.6�20and plate like atelectasis (21.4�20were noted. Bronchial wall thickening (p=0.044) and bronchiectasis (p=0.063) were most prevalent in males. Ten (35.7�20patients exhibited mild, 9 (32.1�20had moderate and 3 (10.7�20had severe air trapping. The difference in Hounsfield units between expiratory and inspiratory slices (air trapping) when correlated with percent-predicted FEV1 in right upper (r=0.25;p=0.30), left upper (r=0.20; p=0.41), right mid (r=0.15; p=0.53), left mid (r=-0.04; p=0.60), right lower (r=0.04; p=0.86) and left lower zones (r=-0.13; p=0.58) showed no relation. The same when correlated as above with the percent predicted FEF 25-75 did not show any significant association. The presence of air trapping was compared with sex (p=0.640), nationality (p=1.000), disease duration (p=1.000) and severity of symptoms (p=0.581).Conclusion: Abnormal HRCT findings are common in asthma; however, air trapping when present was not related to the duration or severity of the illness or to the FEV1.