A tRNA half modulates translation as stress response in Trypanosoma brucei

Trypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.

Bibliographic Details
Main Authors:	Roger Fricker, Rebecca Brogli, Hannes Luidalepp, Leander Wyss, Michel Fasnacht, Oliver Joss, Marek Zywicki, Mark Helm, André Schneider, Marina Cristodero, Norbert Polacek
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07949-6

id	doaj-1d23c87897e1460f9d583fc47617f772
record_format	Article
spelling	doaj-1d23c87897e1460f9d583fc47617f7722021-05-11T11:26:56ZengNature Publishing GroupNature Communications2041-17232019-01-0110111210.1038/s41467-018-07949-6A tRNA half modulates translation as stress response in Trypanosoma bruceiRoger Fricker0Rebecca Brogli1Hannes Luidalepp2Leander Wyss3Michel Fasnacht4Oliver Joss5Marek Zywicki6Mark Helm7André Schneider8Marina Cristodero9Norbert Polacek10Department of Chemistry and Biochemistry, University of BernDepartment of Chemistry and Biochemistry, University of BernDepartment of Chemistry and Biochemistry, University of BernDepartment of Chemistry and Biochemistry, University of BernDepartment of Chemistry and Biochemistry, University of BernDepartment of Chemistry and Biochemistry, University of BernDepartment of Computational Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz UniversityInstitute of Pharmacy and Biochemistry, Johannes Gutenberg-University of MainzDepartment of Chemistry and Biochemistry, University of BernDepartment of Chemistry and Biochemistry, University of BernDepartment of Chemistry and Biochemistry, University of BernTrypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.https://doi.org/10.1038/s41467-018-07949-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Roger Fricker Rebecca Brogli Hannes Luidalepp Leander Wyss Michel Fasnacht Oliver Joss Marek Zywicki Mark Helm André Schneider Marina Cristodero Norbert Polacek
spellingShingle	Roger Fricker Rebecca Brogli Hannes Luidalepp Leander Wyss Michel Fasnacht Oliver Joss Marek Zywicki Mark Helm André Schneider Marina Cristodero Norbert Polacek A tRNA half modulates translation as stress response in Trypanosoma brucei Nature Communications
author_facet	Roger Fricker Rebecca Brogli Hannes Luidalepp Leander Wyss Michel Fasnacht Oliver Joss Marek Zywicki Mark Helm André Schneider Marina Cristodero Norbert Polacek
author_sort	Roger Fricker
title	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_short	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_full	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_fullStr	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_full_unstemmed	A tRNA half modulates translation as stress response in Trypanosoma brucei
title_sort	trna half modulates translation as stress response in trypanosoma brucei
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-01-01
description	Trypanosoma brucei mainly relies on translational regulation to adjust gene expression, but details are unclear. Here the authors show that, under stress conditions, tRNAThr half level increases, associates with ribosomes and polysomes, and stimulates protein synthesis by facilitating mRNA loading.
url	https://doi.org/10.1038/s41467-018-07949-6
work_keys_str_mv	AT rogerfricker atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT rebeccabrogli atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT hannesluidalepp atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT leanderwyss atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT michelfasnacht atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT oliverjoss atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT marekzywicki atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT markhelm atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT andreschneider atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT marinacristodero atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT norbertpolacek atrnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT rogerfricker trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT rebeccabrogli trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT hannesluidalepp trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT leanderwyss trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT michelfasnacht trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT oliverjoss trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT marekzywicki trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT markhelm trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT andreschneider trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT marinacristodero trnahalfmodulatestranslationasstressresponseintrypanosomabrucei AT norbertpolacek trnahalfmodulatestranslationasstressresponseintrypanosomabrucei
_version_	1721446497998864384

A tRNA half modulates translation as stress response in Trypanosoma brucei

Similar Items