PBRM1 Regulates Stress Response in Epithelial Cells
Summary: Polybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly clear cell renal carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm-associated factors), and is characterized by six tandem bromodomains. Here we establish a role for PBRM1 i...
Main Authors: | Elizabeth G. Porter, Alisha Dhiman, Basudev Chowdhury, Benjamin C. Carter, Hang Lin, Jane C. Stewart, Majid Kazemian, Michael K. Wendt, Emily C. Dykhuizen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-05-01
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Series: | iScience |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219301245 |
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