A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

The guanine nucleotide exchange factor Vav1 is essential for transducing T cell receptor (TCR) signals and plays an important role in T cell development and activation. Previous genetic studies identified a natural variant of Vav1 characterized by the substitution of an arginine (R) residue by a try...

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Bibliographic Details
Main Authors: Isabelle Bernard, Antoine Sacquin, Sahar Kassem, Mehdi Benamar, Céline Colacios, Mylène Gador, Corine Pérals, Nicolas Fazilleau, Abdelhadi Saoudi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
myasthenia gravis
T cells
Vav1
animal models
T cell repertoire
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02399/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02399/full

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