Targeted two-photon chemical apoptotic ablation of defined cell types in vivo

Targeted two-photon chemical apoptotic ablation of defined cell types in vivo

Investigating cell death in living organisms is hampered by a lack of techniques to induce apoptosis with spatial and temporal precision without collateral damage. Here the authors develop two-photon chemical apoptotic targeted ablation (2Phatal), allowing studies of apoptosis and its functional con...

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Main Authors: Robert A. Hill, Eyiyemisi C. Damisah, Fuyi Chen, Alex C. Kwan, Jaime Grutzendler
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15837
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spelling doaj-1d11ab96b908497fa624c67b497b80692021-05-11T07:08:32ZengNature Publishing GroupNature Communications2041-17232017-06-018111510.1038/ncomms15837Targeted two-photon chemical apoptotic ablation of defined cell types in vivoRobert A. Hill0Eyiyemisi C. Damisah1Fuyi Chen2Alex C. Kwan3Jaime Grutzendler4Department of Neurology, Yale School of MedicineDepartment of Neurology, Yale School of MedicineDepartment of Neurology, Yale School of MedicineDepartment of Neuroscience, Yale School of MedicineDepartment of Neurology, Yale School of MedicineInvestigating cell death in living organisms is hampered by a lack of techniques to induce apoptosis with spatial and temporal precision without collateral damage. Here the authors develop two-photon chemical apoptotic targeted ablation (2Phatal), allowing studies of apoptosis and its functional consequencesin vivo.https://doi.org/10.1038/ncomms15837
collection DOAJ
language English
format Article
sources DOAJ
author Robert A. Hill
Eyiyemisi C. Damisah
Fuyi Chen
Alex C. Kwan
Jaime Grutzendler
spellingShingle Robert A. Hill
Eyiyemisi C. Damisah
Fuyi Chen
Alex C. Kwan
Jaime Grutzendler
Targeted two-photon chemical apoptotic ablation of defined cell types in vivo
Nature Communications
author_facet Robert A. Hill
Eyiyemisi C. Damisah
Fuyi Chen
Alex C. Kwan
Jaime Grutzendler
author_sort Robert A. Hill
title Targeted two-photon chemical apoptotic ablation of defined cell types in vivo
title_short Targeted two-photon chemical apoptotic ablation of defined cell types in vivo
title_full Targeted two-photon chemical apoptotic ablation of defined cell types in vivo
title_fullStr Targeted two-photon chemical apoptotic ablation of defined cell types in vivo
title_full_unstemmed Targeted two-photon chemical apoptotic ablation of defined cell types in vivo
title_sort targeted two-photon chemical apoptotic ablation of defined cell types in vivo
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Investigating cell death in living organisms is hampered by a lack of techniques to induce apoptosis with spatial and temporal precision without collateral damage. Here the authors develop two-photon chemical apoptotic targeted ablation (2Phatal), allowing studies of apoptosis and its functional consequencesin vivo.
url https://doi.org/10.1038/ncomms15837
work_keys_str_mv AT robertahill targetedtwophotonchemicalapoptoticablationofdefinedcelltypesinvivo
AT eyiyemisicdamisah targetedtwophotonchemicalapoptoticablationofdefinedcelltypesinvivo
AT fuyichen targetedtwophotonchemicalapoptoticablationofdefinedcelltypesinvivo
AT alexckwan targetedtwophotonchemicalapoptoticablationofdefinedcelltypesinvivo
AT jaimegrutzendler targetedtwophotonchemicalapoptoticablationofdefinedcelltypesinvivo
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