Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review

Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far. Hirudin has been demonstrated to possess potent anti-thrombotic effect in previous stu...

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Bibliographic Details
Main Authors: Chen Junren, Xie Xiaofang, Zhang Huiqiong, Li Gangmin, Yin Yanpeng, Cao Xiaoyu, Gao Yuqing, Li Yanan, Zhang Yue, Peng Fu, Peng Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.660757/full