Preoperative Repetitive Navigated TMS and Functional White Matter Tractography in a Bilingual Patient with a Brain Tumor in Wernike Area

• Main Authors: Valentina Baro, Samuel Caliri, Luca Sartori, Silvia Facchini, Brando Guarrera, Pietro Zangrossi, Mariagiulia Anglani, Luca Denaro, Domenico d’Avella, Florinda Ferreri, Andrea Landi
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Brain Sciences
• Subjects: transcranial magnetic stimulation; brain tumor; bilingual; language; preoperative mapping; case report
• Online Access: https://www.mdpi.com/2076-3425/11/5/557

Awake surgery and intraoperative neuromonitoring represent the gold standard for surgery of lesion located in language-eloquent areas of the dominant hemisphere, enabling the maximal safe resection while preserving language function. Nevertheless, this functional mapping is invasive; it can be executed only during surgery and in selected patients. Moreover, the number of neuro-oncological bilingual patients is constantly growing, and performing awake surgery in this group of patients can be difficult. In this scenario, the application of accurate, repeatable and non-invasive preoperative mapping procedures is needed, in order to define the anatomical distribution of both languages. Repetitive navigated transcranial magnetic stimulation (rnTMS) associated with functional subcortical fiber tracking (nTMS-based DTI-FT) represents a promising and comprehensive mapping tool to display language pathway and function reorganization in neurosurgical patients. Herein we report a case of a bilingual patient affected by brain tumor in the left temporal lobe, who underwent rnTMS mapping for both languages (Romanian and Italian), disclosing the true eloquence of the anterior part of the lesion in both tests. After surgery, language abilities were intact at follow-up in both languages. This case represents a preliminary application of nTMS-based DTI-FT in neurosurgery for brain tumor in eloquent areas in a bilingual patient.