Myocardial TGFβ2 Is Required for Atrioventricular Cushion Remodeling and Myocardial Development

Myocardial TGFβ2 Is Required for Atrioventricular Cushion Remodeling and Myocardial Development

Among the three transforming growth factor beta (TGFβ) ligands, TGFβ2 is essential for heart development and is produced by multiple cell types, including myocardium. Heterozygous mutations in <i>TGFB2</i> in patients of connective tissue disorders result in congenital heart defects and...

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Bibliographic Details
Main Authors: Aniket Bhattacharya, Nadia Al-Sammarraie, Mengistu G. Gebere, John Johnson, John F. Eberth, Mohamad Azhar
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
TGFβ2
myocardium
atrioventricular cushion
AVSD
mitral valve
SMAD2
Online Access:https://www.mdpi.com/2308-3425/8/3/26

Internet

https://www.mdpi.com/2308-3425/8/3/26

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