Melatonin Downregulates PD-L1 Expression and Modulates Tumor Immunity in KRAS-Mutant Non-Small Cell Lung Cancer

Melatonin Downregulates PD-L1 Expression and Modulates Tumor Immunity in KRAS-Mutant Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) patients harboring a KRAS mutation have unfavorable therapeutic outcomes with chemotherapies, and the mutation also renders tolerance to immunotherapies. There is an unmet need for a new strategy for overcoming immunosuppression in KRAS-mutant NSCLC. The recently d...

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Bibliographic Details
Main Authors: Yi-Chun Chao, Kang-Yun Lee, Sheng-Ming Wu, Deng-Yu Kuo, Pei-Wei Shueng, Cheng-Wei Lin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
lung cancer
PD-L1
tumor immunity
Hippo pathway
Online Access:https://www.mdpi.com/1422-0067/22/11/5649

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