Early adverse life events are associated with altered brain network architecture in a sex- dependent manner

• Main Authors: Arpana Gupta, PhD, Emeran A. Mayer, MD, PhD, Jonathan R. Acosta, BSc, Kareem Hamadani, BSc, Carinna Torgerson, BA, John D. van Horn, PhD, Lin Chang, MD, Bruce Naliboff, PhD, Kirsten Tillisch, MD, Jennifer S. Labus, PhD
• Format: Article
• Language: English
• Published: Elsevier 2017-12-01
• Series: Neurobiology of Stress
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352289516300273

Introduction: Early adverse life events (EALs) increase the risk for chronic medical and psychiatric disorders by altering early neurodevelopment. The aim of this study was to examine associations between EALs and network properties of core brain regions in the emotion regulation and salience networks, and to test the influence of sex on these associations. Methods: Resting-state functional and diffusion tensor magnetic resonance imaging were obtained in healthy individuals (61 men, 63 women). Functional and anatomical network properties of centrality and segregation were calculated for the core regions of the two networks using graph theory. Moderator analyses were applied to test hypotheses. Results: The type of adversity experienced influences brain wiring differently, as higher general EALs were associated with decreased functional and anatomical centrality in salience and emotion regulation regions, while physical and emotional EALs were associated with increased anatomical centrality and segregation in emotion regulation regions. Sex moderated the associations between EALs and measures of centrality; with decreased centrality of salience and emotion regulation regions with increased general EALs in females, and increased centrality in salience regions with higher physical and emotional EALs in males. Increased segregation of salience regions was associated with increased general EALs in males. Centrality of the amygdala was associated with physical symptoms, and segregation of salience regions was correlated with higher somatization in men only. Conclusions: Emotion regulation and salience regions are susceptible to topological brain restructuring associated with EALs. The male and female brains appear to be differently affected by specific types of EALs. Keywords: Early adverse traumatic life events, Centrality, Segregation, Network metrics, Moderating effects of sex, Emotion regulation network, Salience network