BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes
Bone morphogenetic protein (BMP) maintains intestinal homeostasis by restricting its hyperproliferation but whether it directly regulates the stem cells is unknown. Here the authors show that BMP constrains the Lgr5+stem cell expansion under both homeostatic and injury conditions through Smad-mediat...
Full description
Bibliographic Details
| Main Authors: |
Zhen Qi,
Yehua Li,
Bing Zhao,
Chi Xu,
Yuan Liu,
Haonan Li,
Bingjie Zhang,
Xinquan Wang,
Xiao Yang,
Wei Xie,
Baojie Li,
Jing-Dong Jackie Han,
Ye-Guang Chen |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2017-01-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/ncomms13824
|
|---|
