<i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

<i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

<i>Holothuria leucospilota</i> polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 1...

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Main Authors: Yiqiong Yuan, Qibing Liu, Fuqiang Zhao, Jun Cao, Xuanri Shen, Chuan Li
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Holothuria leucospilota</i>
polysaccharides
hyperlipidemia
high-fat diet
short-chain fatty acids
lipid metabolism
gut microbiota
Online Access:https://www.mdpi.com/1422-0067/20/19/4738
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spelling doaj-1cfa3fcc077149c2af1eb66edc7fd4bc2020-11-25T01:22:40ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-09-012019473810.3390/ijms20194738ijms20194738<i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism RegulationYiqiong Yuan0Qibing Liu1Fuqiang Zhao2Jun Cao3Xuanri Shen4Chuan Li5Hainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, ChinaDepartment of Pharmacology, School of Basic Medicine and Life Science, Hainan Medical University, Haikou 571199, ChinaHainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, ChinaHainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, ChinaHainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, ChinaHainan Provincial Engineering Research Centre of Aquatic Resources Efficient Utilization in the South China Sea, Key Laboratory of Marine Food Processing of Haikou, College of Food Science and Engineering, Hainan University, Haikou 570228, China<i>Holothuria leucospilota</i> polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-&#945;, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.https://www.mdpi.com/1422-0067/20/19/4738<i>Holothuria leucospilota</i>polysaccharideshyperlipidemiahigh-fat dietshort-chain fatty acidslipid metabolismgut microbiota
collection DOAJ
language English
format Article
sources DOAJ
author Yiqiong Yuan
Qibing Liu
Fuqiang Zhao
Jun Cao
Xuanri Shen
Chuan Li
spellingShingle Yiqiong Yuan
Qibing Liu
Fuqiang Zhao
Jun Cao
Xuanri Shen
Chuan Li
<i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation
International Journal of Molecular Sciences
<i>Holothuria leucospilota</i>
polysaccharides
hyperlipidemia
high-fat diet
short-chain fatty acids
lipid metabolism
gut microbiota
author_facet Yiqiong Yuan
Qibing Liu
Fuqiang Zhao
Jun Cao
Xuanri Shen
Chuan Li
author_sort Yiqiong Yuan
title <i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation
title_short <i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation
title_full <i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation
title_fullStr <i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation
title_full_unstemmed <i>Holothuria Leucospilota</i> Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation
title_sort <i>holothuria leucospilota</i> polysaccharides ameliorate hyperlipidemia in high-fat diet-induced rats via short-chain fatty acids production and lipid metabolism regulation
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2019-09-01
description <i>Holothuria leucospilota</i> polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-&#945;, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.
topic <i>Holothuria leucospilota</i>
polysaccharides
hyperlipidemia
high-fat diet
short-chain fatty acids
lipid metabolism
gut microbiota
url https://www.mdpi.com/1422-0067/20/19/4738
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