<i>N</i>-Phenyl Cinnamamide Derivatives Protect Hepatocytes Against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation

<i>N</i>-Phenyl Cinnamamide Derivatives Protect Hepatocytes Against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation

Substituted <i>N</i>-phenyl cinnamamide derivatives were designed and synthesized to confirm activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway by the electronic effect on beta-position of Michael acceptor according to introducing the R<sup>1</sup> and R...

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Bibliographic Details
Main Authors: Sou Hyun Kim, Minwoo Kim, Doyoung Kwon, Jae Sung Pyo, Joo Hyun Kim, Jae-Hwan Kwak, Young-Suk Jung
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
N-phenyl cinnamamide
nuclear factor (erythroid-derived 2)-like 2
antioxidant response element
glutathione
Online Access:https://www.mdpi.com/1420-3049/26/4/1027

Internet

https://www.mdpi.com/1420-3049/26/4/1027

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