ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response

Summary: The unfolded protein response (UPR) pathway senses unfolded proteins and regulates proteostasis and cell fate through activity of the transcription factors ATF4, ATF6, and XBP1 within a complex network of three main branches. Here, we investigated contributions of the three branches to UPR...

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Bibliographic Details
Main Authors: Huan Yang, Marije Niemeijer, Bob van de Water, Joost B. Beltman
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220300432

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