Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance.

Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance.

Active efflux due to tripartite RND efflux pumps is an important mechanism of clinically relevant antibiotic resistance in Gram-negative bacteria. These pumps are also essential for Gram-negative pathogens to cause infection and form biofilms. They consist of an inner membrane RND transporter; a per...

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Bibliographic Details
Main Authors: Helen E McNeil, Ilyas Alav, Ricardo Corona Torres, Amanda E Rossiter, Eve Laycock, Simon Legood, Inderpreet Kaur, Matthew Davies, Matthew Wand, Mark A Webber, Vassiliy N Bavro, Jessica M A Blair
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008101

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