Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

Abstract Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole‐genome sequencing (sWGS, at a coverage of < 0.4×)...

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Bibliographic Details
Main Authors: Florent Mouliere, Richard Mair, Dineika Chandrananda, Francesco Marass, Christopher G Smith, Jing Su, James Morris, Colin Watts, Kevin M Brindle, Nitzan Rosenfeld
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:EMBO Molecular Medicine
Subjects:
cell‐free DNA
cerebrospinal fluid
fragmentation
glioma
shallow WGS
Online Access:https://doi.org/10.15252/emmm.201809323

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