EGFR and KRAS Mutations Predict the Incidence and Outcome of Brain Metastases in Non-Small Cell Lung Cancer

EGFR and KRAS Mutations Predict the Incidence and Outcome of Brain Metastases in Non-Small Cell Lung Cancer

Background: Lung cancer is the leading cause of brain metastases (BM). The identification of driver oncogenes and matched targeted therapies has improved outcome in non-small cell lung cancer (NSCLC) patients; however, a better understanding of BM molecular biology is needed to further drive the pro...

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Bibliographic Details
Main Authors: Pascale Tomasini, Cindy Serdjebi, Nataliya Khobta, Philippe Metellus, L’Houcine Ouafik, Isabelle Nanni, Laurent Greillier, Anderson Loundou, Frederic Fina, Celine Mascaux, Fabrice Barlesi
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
brain metastasis
lung neoplasm
KRAS
EGFR
incidence
recurrence
survival
Online Access:http://www.mdpi.com/1422-0067/17/12/2132

Internet

http://www.mdpi.com/1422-0067/17/12/2132

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