The cerebral tremor circuit in a patient with Holmes tremor
Abstract The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe...
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Wiley
2020-08-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51143 |
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doaj-1ce298ed94694a6b947217270e6343c92021-05-02T23:51:09ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-08-01781453145810.1002/acn3.51143The cerebral tremor circuit in a patient with Holmes tremorFreek Nieuwhof0Rob M.A. deBie1Peter Praamstra2Pepijn van denMunckhof3Rick C. Helmich4Centre for Cognitive Neuroimaging Donders Institute for Brain, Cognition and BehaviourRadboud University Nijmegen The NetherlandsDepartment of Neurology Amsterdam UMC ‐ Locatie AMCAmsterdam Neuroscience Amsterdam The NetherlandsDepartment of Neurology Center of Expertise for Parkinson & Movement Disorders Donders Institute for Brain, Cognition and BehaviourRadboud University Medical Centre Nijmegen The NetherlandsDepartment of Neurosurgery Amsterdam UMC ‐ Locatie AMCUniversity of Amsterdam Amsterdam The NetherlandsCentre for Cognitive Neuroimaging Donders Institute for Brain, Cognition and BehaviourRadboud University Nijmegen The NetherlandsAbstract The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sided tremor caused by a microbleed near the right red nucleus. Using accelerometry‐fMRI, we show tremor‐related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom‐related activity.https://doi.org/10.1002/acn3.51143 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Freek Nieuwhof Rob M.A. deBie Peter Praamstra Pepijn van denMunckhof Rick C. Helmich |
| spellingShingle |
Freek Nieuwhof Rob M.A. deBie Peter Praamstra Pepijn van denMunckhof Rick C. Helmich The cerebral tremor circuit in a patient with Holmes tremor Annals of Clinical and Translational Neurology |
| author_facet |
Freek Nieuwhof Rob M.A. deBie Peter Praamstra Pepijn van denMunckhof Rick C. Helmich |
| author_sort |
Freek Nieuwhof |
| title |
The cerebral tremor circuit in a patient with Holmes tremor |
| title_short |
The cerebral tremor circuit in a patient with Holmes tremor |
| title_full |
The cerebral tremor circuit in a patient with Holmes tremor |
| title_fullStr |
The cerebral tremor circuit in a patient with Holmes tremor |
| title_full_unstemmed |
The cerebral tremor circuit in a patient with Holmes tremor |
| title_sort |
cerebral tremor circuit in a patient with holmes tremor |
| publisher |
Wiley |
| series |
Annals of Clinical and Translational Neurology |
| issn |
2328-9503 |
| publishDate |
2020-08-01 |
| description |
Abstract The cerebral network associated with Holmes tremor has never been determined directly. A previous study reported a brain network that is functionally connected, in healthy individuals, to different lesions that cause Holmes tremor (lesion connectome). We report a 71‐year‐old man with severe left‐sided tremor caused by a microbleed near the right red nucleus. Using accelerometry‐fMRI, we show tremor‐related activity in contralateral sensorimotor cortex and cerebellar vermis. This network was distinct from, but functionally coupled to, the Holmes lesion connectome. We propose that Holmes tremor involves three distinct cerebral mechanisms: a structural lesion, an intermediate lesion connectome, and symptom‐related activity. |
| url |
https://doi.org/10.1002/acn3.51143 |
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