Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation

Hyperbaric Oxygen Treatment Ameliorates Hearing Loss and Auditory Cortex Injury in Noise Exposed Mice by Repressing Local Ceramide Accumulation

Noise-induced hearing loss (NIHL) relates closely to auditory cortex (AC) injury, so countermeasures aiming at the AC recovery would be of benefit. In this work, the effect of hyperbaric oxygen treatment on NIHL was elucidated, which was imposed on mice before (HBOP), during (HBOD) or after (HBOA) n...

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Bibliographic Details
Main Authors: Yu-Ting Su, Yi-Bin Guo, Yao-Ping Cheng, Xi Zhang, Xiao-Ping Xie, Yao-Ming Chang, Jun-Xiang Bao
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
hyperbaric oxygen therapy
noise
hearing loss
ceramide
acid sphingomyelinase
acid ceramidase
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/20/19/4675

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