Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors
Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual developme...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-11-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/2/4/2026/ |
| Summary: | Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Currently, there is a bulk of data indicating the important function of autophagy in cancer. While genetic evidence indicates that autophagy functions as a tumor suppressor, it is also apparent that autophagy can promote the survival of established tumors under stress conditions and in response to chemotherapy. This review provides a spectrum of potential pharmacological agents and autophagic approaches to enhance cell killing in pancreatic cancer. |
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| ISSN: | 2072-6694 |