| Summary: | <i>Background and Objectives</i>: Quality of life (QOL) assessment during pregnancy contributes to determining women’s unmet needs and preventing negative health outcomes. In this study, we aimed to identify the effects of participants’ characteristics, perceived stress, and perceived social support on their QOL. We also aimed to determine the differences in QOL according to these factors. <i>Materials and Methods</i>: A cross-sectional study was carried out in a city in Jordan. Purposive sampling was used to select 218 participants. Data was collected by the quality of life Short Form- 36(SF-36) survey, perceived stress scale (PSS), and The Multidimensional perceived Social Support Scale (MSPSS). <i>Results</i>: We found that only parity had a significant effect on the QOL. High-parity women had lower QOL scores than low-parity women. The participants reported high social support, specifically from their families and significant others. The 36-Item Short-Form Health Survey was a reliable tool for measuring the QOL in pregnancy. <i>Conclusions</i>: Parity factor and social support should be recognized in any health promotion intervention and during providing antenatal care. Further research is needed toassess the QOL during pregnancy.
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