Effect of budesonide inhalation combined with azithromycin on pulmonary function, serum inflammatory factors and immune function of children with mycoplasma pneumonia

• Main Authors: Yi-Lin Tan, Chi-Lin Ye
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-11-01
• Series: Journal of Hainan Medical University
• Subjects: Children; Mycoplasma pneumonia; Budesonide azithromycin; Lung function; Inflammatory factor; Immune function
• Online Access: http://www.hnykdxxb.com/PDF/201622/38.pdf

Objective: To observe the effect of budesonide inhalation combined with azithromycin on pulmonary function ,serum inflammatory factors and immune function of children with mycoplasma pneumonia. Methods: A total of 128 cases of children with MPP were selected from June 2014 to May 2016 and were randomly divided into observation group (68 cases) and control group (60 cases).The control group were treated with azithromycin while the observation group were given both budesonide aerosol inhalation and azithromycin therapy. After two weeks, observe two groups of lung function index (FVC, FEV1, PEV and PEF25), the serum levels of inflammatory factors (TNF-α, IL-2, IL-6, INF-γ) and the immune function (IgM, IgG, IgA). Results: After treatment, the level of FEV1, FVC, PEV and PEF25 of the two group were increased compared with before (P<0.05), and the FEV1, FVC, PEV and PEF25 of observation group after treatment were respectively significantly higher than the control group (P<0.05). TNFα, IL-2, IL-6 and INF-γ in both groups were decreased compared with before (P<0.05), and the TNFα, IL-2, IL-6 and INF-γ of observation group after treatment were significantly lower than the control group (P<0.05). IgM and IgA were decreased while the IgG was increased (P<0.05), the observation group was significantly lower than control group (P<0.05). Conclusion: Budesonide aerosol inhalation in combination with azithromycin can significantly improve lung function, inhibit inflammation and regulate immune function strongly than that of azithromycin alone in treatment of children MPP.