Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology

Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology

Abnormal tau hyperphosphorylation and its aggregation into neurofibrillary tangles are a hallmark of tauopathies, neurodegenerative disorders that include Alzheimer's disease (AD). Active and passive Tau-immunotherapy has been proposed as a therapeutic approach to AD with mixed results. One of...

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Bibliographic Details
Main Authors: A. Joly-Amado, H. Davtyan, K. Serraneau, P. Jules, A. Zitnyar, E. Pressman, K. Zagorski, T. Antonyan, A. Hovakimyan, H.J. Paek, M.N. Gordon, D.H. Cribbs, N. Petrovsky, M.G. Agadjanyan, A. Ghochikyan, D. Morgan
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303110

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