Novel sequence variations in LAMA2 and SGCG genes modulating cis-acting regulatory elements and RNA secondary structure

Novel sequence variations in LAMA2 and SGCG genes modulating cis-acting regulatory elements and RNA secondary structure

In this study, we detected new sequence variations in LAMA2 and SGCG genes in 5 ethnic populations, and analysed their effect on enhancer composition and mRNA structure. PCR amplification and DNA sequencing were performed and followed by bioinformatics analyses using ESEfinder as well as MFOLD softw...

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Bibliographic Details
Main Authors: Olfa Siala, Ikhlass Hadj Salem, Abdelaziz Tlili, Imen Ammar, Hanen Belguith, Faiza Fakhfakh
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2010-01-01
Series:Genetics and Molecular Biology
Subjects:
muscular dystrophies
exon splicing enhancer
RNA fold
SR proteins
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000100032

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