Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model

Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model

Ruthenium complexes with piplartine, [Ru(piplartine)(dppf)(bipy)](PF6)2 (1) and [Ru(piplartine)(dppb)(bipy)](PF6)2 (2) (dppf = 1,1-bis(diphenylphosphino) ferrocene; dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine), were recently synthesized and displayed more potent cytotoxicity t...

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Bibliographic Details
Main Authors: Ingrid R. S. Baliza, Suellen L. R. Silva, Luciano de S. Santos, João H. Araujo Neto, Rosane B. Dias, Caroline B. S. Sales, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Alzir A. Batista, Daniel P. Bezerra
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Oncology
Subjects:
ruthenium complexes
piplartine
piperlongumine
apoptosis
MAPK
p53
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00582/full

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