Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions

Human MAIT cells endowed with HBV specificity are cytotoxic and migrate towards HBV-HCC while retaining antimicrobial functions

Background & Aims: Virus-specific T cell dysfunction is a common feature of HBV-related hepatocellular carcinoma (HBV-HCC). Conventional T (ConT) cells can be redirected towards viral antigens in HBV-HCC when they express an HBV-specific receptor; however, their efficacy can be impaired by l...

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Bibliographic Details
Main Authors: Katie Healy, Andrea Pavesi, Tiphaine Parrot, Michał J. Sobkowiak, Susanne E. Reinsbach, Haleh Davanian, Anthony T. Tan, Soo Aleman, Johan K. Sandberg, Antonio Bertoletti, Margaret Sällberg Chen
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:JHEP Reports
Subjects:
HCC
HBV
Adoptive cell transfer
MAIT cells
TCR-T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S258955592100094X

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