The Role of Macrophages in Staphylococcus aureus Infection

Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infe...

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Main Authors: Grace R. Pidwill, Josie F. Gibson, Joby Cole, Stephen A. Renshaw, Simon J. Foster
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.620339/full
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spelling doaj-1c8d7b5ba7ff40bc9a197f2c6cc650cf2021-01-19T04:31:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-01-011110.3389/fimmu.2020.620339620339The Role of Macrophages in Staphylococcus aureus InfectionGrace R. Pidwill0Grace R. Pidwill1Josie F. Gibson2Josie F. Gibson3Josie F. Gibson4Joby Cole5Joby Cole6Stephen A. Renshaw7Stephen A. Renshaw8Stephen A. Renshaw9Simon J. Foster10Simon J. Foster11Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomThe Bateson Centre, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomThe Bateson Centre, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United KingdomDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomStaphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infection. Professional phagocytes, primarily macrophages and neutrophils, are key innate immune cells which interact with S. aureus, acting as gatekeepers to contain and resolve infection. Recent studies have highlighted the important roles of macrophages during S. aureus infections, using a wide array of killing mechanisms. In defense, S. aureus has evolved multiple strategies to survive within, manipulate and escape from macrophages, allowing them to not only subvert but also exploit this key element of our immune system. Macrophage-S. aureus interactions are multifaceted and have direct roles in infection outcome. In depth understanding of these host-pathogen interactions may be useful for future therapeutic developments. This review examines macrophage interactions with S. aureus throughout all stages of infection, with special emphasis on mechanisms that determine infection outcome.https://www.frontiersin.org/articles/10.3389/fimmu.2020.620339/fullmacrophageStaphylococcusphagocytosisimmunityimmune evasion
collection DOAJ
language English
format Article
sources DOAJ
author Grace R. Pidwill
Grace R. Pidwill
Josie F. Gibson
Josie F. Gibson
Josie F. Gibson
Joby Cole
Joby Cole
Stephen A. Renshaw
Stephen A. Renshaw
Stephen A. Renshaw
Simon J. Foster
Simon J. Foster
spellingShingle Grace R. Pidwill
Grace R. Pidwill
Josie F. Gibson
Josie F. Gibson
Josie F. Gibson
Joby Cole
Joby Cole
Stephen A. Renshaw
Stephen A. Renshaw
Stephen A. Renshaw
Simon J. Foster
Simon J. Foster
The Role of Macrophages in Staphylococcus aureus Infection
Frontiers in Immunology
macrophage
Staphylococcus
phagocytosis
immunity
immune evasion
author_facet Grace R. Pidwill
Grace R. Pidwill
Josie F. Gibson
Josie F. Gibson
Josie F. Gibson
Joby Cole
Joby Cole
Stephen A. Renshaw
Stephen A. Renshaw
Stephen A. Renshaw
Simon J. Foster
Simon J. Foster
author_sort Grace R. Pidwill
title The Role of Macrophages in Staphylococcus aureus Infection
title_short The Role of Macrophages in Staphylococcus aureus Infection
title_full The Role of Macrophages in Staphylococcus aureus Infection
title_fullStr The Role of Macrophages in Staphylococcus aureus Infection
title_full_unstemmed The Role of Macrophages in Staphylococcus aureus Infection
title_sort role of macrophages in staphylococcus aureus infection
publisher Frontiers Media S.A.
series Frontiers in Immunology
issn 1664-3224
publishDate 2021-01-01
description Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infection. Professional phagocytes, primarily macrophages and neutrophils, are key innate immune cells which interact with S. aureus, acting as gatekeepers to contain and resolve infection. Recent studies have highlighted the important roles of macrophages during S. aureus infections, using a wide array of killing mechanisms. In defense, S. aureus has evolved multiple strategies to survive within, manipulate and escape from macrophages, allowing them to not only subvert but also exploit this key element of our immune system. Macrophage-S. aureus interactions are multifaceted and have direct roles in infection outcome. In depth understanding of these host-pathogen interactions may be useful for future therapeutic developments. This review examines macrophage interactions with S. aureus throughout all stages of infection, with special emphasis on mechanisms that determine infection outcome.
topic macrophage
Staphylococcus
phagocytosis
immunity
immune evasion
url https://www.frontiersin.org/articles/10.3389/fimmu.2020.620339/full
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