The Role of Macrophages in Staphylococcus aureus Infection
Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infe...
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doaj-1c8d7b5ba7ff40bc9a197f2c6cc650cf2021-01-19T04:31:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-01-011110.3389/fimmu.2020.620339620339The Role of Macrophages in Staphylococcus aureus InfectionGrace R. Pidwill0Grace R. Pidwill1Josie F. Gibson2Josie F. Gibson3Josie F. Gibson4Joby Cole5Joby Cole6Stephen A. Renshaw7Stephen A. Renshaw8Stephen A. Renshaw9Simon J. Foster10Simon J. Foster11Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomThe Bateson Centre, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomThe Bateson Centre, University of Sheffield, Sheffield, United KingdomDepartment of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United KingdomDepartment of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United KingdomFlorey Institute, University of Sheffield, Sheffield, United KingdomStaphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infection. Professional phagocytes, primarily macrophages and neutrophils, are key innate immune cells which interact with S. aureus, acting as gatekeepers to contain and resolve infection. Recent studies have highlighted the important roles of macrophages during S. aureus infections, using a wide array of killing mechanisms. In defense, S. aureus has evolved multiple strategies to survive within, manipulate and escape from macrophages, allowing them to not only subvert but also exploit this key element of our immune system. Macrophage-S. aureus interactions are multifaceted and have direct roles in infection outcome. In depth understanding of these host-pathogen interactions may be useful for future therapeutic developments. This review examines macrophage interactions with S. aureus throughout all stages of infection, with special emphasis on mechanisms that determine infection outcome.https://www.frontiersin.org/articles/10.3389/fimmu.2020.620339/fullmacrophageStaphylococcusphagocytosisimmunityimmune evasion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Grace R. Pidwill Grace R. Pidwill Josie F. Gibson Josie F. Gibson Josie F. Gibson Joby Cole Joby Cole Stephen A. Renshaw Stephen A. Renshaw Stephen A. Renshaw Simon J. Foster Simon J. Foster |
spellingShingle |
Grace R. Pidwill Grace R. Pidwill Josie F. Gibson Josie F. Gibson Josie F. Gibson Joby Cole Joby Cole Stephen A. Renshaw Stephen A. Renshaw Stephen A. Renshaw Simon J. Foster Simon J. Foster The Role of Macrophages in Staphylococcus aureus Infection Frontiers in Immunology macrophage Staphylococcus phagocytosis immunity immune evasion |
author_facet |
Grace R. Pidwill Grace R. Pidwill Josie F. Gibson Josie F. Gibson Josie F. Gibson Joby Cole Joby Cole Stephen A. Renshaw Stephen A. Renshaw Stephen A. Renshaw Simon J. Foster Simon J. Foster |
author_sort |
Grace R. Pidwill |
title |
The Role of Macrophages in Staphylococcus aureus Infection |
title_short |
The Role of Macrophages in Staphylococcus aureus Infection |
title_full |
The Role of Macrophages in Staphylococcus aureus Infection |
title_fullStr |
The Role of Macrophages in Staphylococcus aureus Infection |
title_full_unstemmed |
The Role of Macrophages in Staphylococcus aureus Infection |
title_sort |
role of macrophages in staphylococcus aureus infection |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-01-01 |
description |
Staphylococcus aureus is a member of the human commensal microflora that exists, apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it can also cause a range of serious diseases. This requires an ability to circumvent the innate immune system to establish an infection. Professional phagocytes, primarily macrophages and neutrophils, are key innate immune cells which interact with S. aureus, acting as gatekeepers to contain and resolve infection. Recent studies have highlighted the important roles of macrophages during S. aureus infections, using a wide array of killing mechanisms. In defense, S. aureus has evolved multiple strategies to survive within, manipulate and escape from macrophages, allowing them to not only subvert but also exploit this key element of our immune system. Macrophage-S. aureus interactions are multifaceted and have direct roles in infection outcome. In depth understanding of these host-pathogen interactions may be useful for future therapeutic developments. This review examines macrophage interactions with S. aureus throughout all stages of infection, with special emphasis on mechanisms that determine infection outcome. |
topic |
macrophage Staphylococcus phagocytosis immunity immune evasion |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.620339/full |
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