The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response.

The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response.

Dysregulation of collagen production and secretion contributes to aging and tissue fibrosis of major organs. How procollagen proteins in the endoplasmic reticulum (ER) route as specialized cargos for secretion remains to be fully elucidated. Here, we report that TMEM39, an ER-localized transmembrane...

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Bibliographic Details
Main Authors: Zhe Zhang, Shuo Luo, Guilherme Oliveira Barbosa, Meirong Bai, Thomas B Kornberg, Dengke K Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009317

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