Progressive Metaplastic and Dysplastic Changes in Mouse Pancreas Induced by Cyclooxygenase-2 Overexpression

Progressive Metaplastic and Dysplastic Changes in Mouse Pancreas Induced by Cyclooxygenase-2 Overexpression

Cyclooxygenase-2 (COX-2) overexpression is an established factor linking chronic inflammation with metaplastic and neoplastic change in various tissues. We generated transgenic mice (BK5.COX-2) in which elevation of COX-2 and its effectors trigger a metaplasia-dysplasia sequence in exocrine pancrea...

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Bibliographic Details
Main Authors: Jennifer K.L. Colby, Russell D. Klein, Mark J. McArthur, Claudio J. Conti, Kaoru Kiguchi, Toru Kawamoto, Penny K. Riggs, Amy I. Pavone, Janet Sawicki, Susan M. Fischer
Format: Article
Language:English
Published: Elsevier 2008-08-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608800322

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http://www.sciencedirect.com/science/article/pii/S1476558608800322

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