Thymoma-associated T-cell immunodeficiency after radiotherapy: A case report

• Main Authors: Kensuke Nakagawara, Shotaro Chubachi, Shuhei Azekawa, Shiro Otake, Ayaka Saito, Masahiko Okada, Ko Lee, Katsunori Masaki, Naoyoshi Koike, Hirofumi Kamata, Ichiro Kawada, Shigeaki Suzuki, Makoto Ishii, Koichi Fukunaga
• Format: Article
• Language: English
• Published: Elsevier 2021-01-01
• Series: Respiratory Medicine Case Reports
• Subjects: Thymoma; T-cell immunodeficiency; Myasthenia gravis; Radiotherapy; Oral candidiasis; Pneumoniae
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213007121000708
• ISSN: 2213-0071

Acquired immunodeficiency in thymoma (Good's syndrome) without hypogammaglobulinemia is a rare condition. Here we describe the case of a 29-year-old Japanese woman with thymoma-associated T cell immunodeficiency after radiation therapy. She was admitted to the hospital with refractory pneumonia, which resulted from as T cell immunodeficiency, as revealed through low peripheral lymphocytes and oral candidiasis triggered through radiotherapy and required long-term antimicrobial therapy. Although radiotherapy is commonly administered for thymoma, our findings suggest that physicians should consider carrying out lymphocyte counts during thymoma treatment.