ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during si...

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Main Authors: Jia-Shu Yang, Jia-Wei Hsu, Seung-Yeol Park, Stella Y. Lee, Jian Li, Ming Bai, Claudia Alves, William Tseng, Xavier Michelet, I-Cheng Ho, Victor W. Hsu
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11932-0
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spelling doaj-1c893257dab047c3a63455ff031c0ff72021-05-11T11:55:09ZengNature Publishing GroupNature Communications2041-17232019-09-0110111610.1038/s41467-019-11932-0ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasisJia-Shu Yang0Jia-Wei Hsu1Seung-Yeol Park2Stella Y. Lee3Jian Li4Ming Bai5Claudia Alves6William Tseng7Xavier Michelet8I-Cheng Ho9Victor W. Hsu10Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Biology, Kansas State UniversityDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolDivision of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical SchoolIntracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during situations of energy deprivationhttps://doi.org/10.1038/s41467-019-11932-0
collection DOAJ
language English
format Article
sources DOAJ
author Jia-Shu Yang
Jia-Wei Hsu
Seung-Yeol Park
Stella Y. Lee
Jian Li
Ming Bai
Claudia Alves
William Tseng
Xavier Michelet
I-Cheng Ho
Victor W. Hsu
spellingShingle Jia-Shu Yang
Jia-Wei Hsu
Seung-Yeol Park
Stella Y. Lee
Jian Li
Ming Bai
Claudia Alves
William Tseng
Xavier Michelet
I-Cheng Ho
Victor W. Hsu
ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
Nature Communications
author_facet Jia-Shu Yang
Jia-Wei Hsu
Seung-Yeol Park
Stella Y. Lee
Jian Li
Ming Bai
Claudia Alves
William Tseng
Xavier Michelet
I-Cheng Ho
Victor W. Hsu
author_sort Jia-Shu Yang
title ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_short ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_full ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_fullStr ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_full_unstemmed ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
title_sort aldh7a1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description Intracellular vesicle transport can be regulated by Brefeldin‐A ADP‐Ribosylated Substrate (BARS) during vesicle fission. Here, the authors show that NADH generated by aldehyde dehydrogenase 7A1 (ALDH7A1) inhibits intracellular transport by targeting BARS and inhibiting COPI vesicle fission during situations of energy deprivation
url https://doi.org/10.1038/s41467-019-11932-0
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