Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch

Lysine specific demethylase 1 (LSD1) is a key epigenetic eraser enzyme implicated in cancer metastases and recurrence. Nuclear LSD1 phosphorylated at serine 111 (nLSD1p) has been shown to be critical for the development of breast cancer stem cells. Here we show that circulating tumor cells isolated...

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Bibliographic Details
Main Authors: Wen Juan Tu, Robert D. McCuaig, Abel H. Y. Tan, Kristine Hardy, Nabila Seddiki, Sayed Ali, Jane E. Dahlstrom, Elaine G. Bean, Jenny Dunn, Jade Forwood, Sofia Tsimbalyuk, Kate Smith, Desmond Yip, Laeeq Malik, Thiru Prasanna, Peter Milburn, Sudha Rao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
cancer
circulating tumor cells
EOMES
immunotherapy resistance
LSD1
PD-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01228/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01228/full

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