Melatonin Prevents Brain Damage and Neurocognitive Impairment Induced by Plasmodium Berghei ANKA Infection in Murine Model of Cerebral Malaria

Melatonin Prevents Brain Damage and Neurocognitive Impairment Induced by Plasmodium Berghei ANKA Infection in Murine Model of Cerebral Malaria

Cerebral malaria is characterized by permanent cognitive impairments in Plasmodium-infected children. Antimalarial therapies show little effectiveness to avoid neurological deficits and brain tissue alterations elicited by severe malaria. Melatonin is a well-recognized endogenous hormone involved in...

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Bibliographic Details
Main Authors: Brenda Jaqueline de Azevedo Ataide, Nayara Kauffmann, Nívia de Souza Franco Mendes, Marjorie Lujan Marques Torres, Larissa Medeiros dos Anjos, Adelaide da Conceição Fonseca Passos, Suellen Alessandra Soares de Moraes, Evander de Jesus Oliveira Batista, Anderson Manoel Herculano, Karen Renata Herculano Matos Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cerebral malaria
melatonin
blood–brain barrier
neurobehavioral impairment
Plasmodium
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.541624/full

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