DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS

Objective: To find the diagnostic accuracy of first trimester hyperuricemia for the prediction of development of subsequent gestational diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Conducted at department of Obstetrics & Gynaecology, Combined Militar...

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Main Authors: Aiza Rehman, Saima Qamar, Humaira Osman Jaffery, Uzma Asif, Faiza Ibrar
Format: Article
Language:English
Published: The Army Press 2020-10-01
Series:Pakistan Armed Forces Medical Journal
Subjects:
Online Access:https://pafmj.org/index.php/PAFMJ/article/view/5577
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spelling doaj-1c7b6e2679b8449d8ed674364a5790912021-09-13T04:19:58ZengThe Army PressPakistan Armed Forces Medical Journal0030-96482411-88422020-10-0170515861589DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUSAiza Rehman0Saima Qamar1Humaira Osman Jaffery2Uzma Asif3Faiza Ibrar4Combined Military Hospital Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital Lahore Medical College, Lahore/National University of Medical Sciences (NUMS) PakistanIslam Medical College, Sialkot PakistanFauji Foundation Hospital, Rawalpindi PaksitanObjective: To find the diagnostic accuracy of first trimester hyperuricemia for the prediction of development of subsequent gestational diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Conducted at department of Obstetrics & Gynaecology, Combined Military Hospital Lahore, from Apr 2017 to Oct 2017. Methodology: All pregnant patients who met the inclusion criteria were enrolled in this study after informed consent. Blood samples in first trimester were collected for analysis of serum uric acid. Then after 24-28 weeks of gestation, Oral glucose tolerance test was done and presence of gestational diabetes mellitus was recorded. All the data were collected on a proforma. Results: The mean age of females was 26.70 ± 5.21 years. The mean height and weight was 1.62 ± 0.07 meters and 61.07 ± 8.54 kg respectively. Body mass index of patients was 23.32 ± 3.72 kg/m2. The mean gestational age of females was 9.96 ± 0.37 weeks at time of enrolment in the study. The mean uric acid level at time of presentation was 4.43 ± 3.61 mg/dl. In this study, the sensitivity and specificity of hyperuricemia for prediction of gestational diabetes mellitus were 91.1% and 95.7%. The positive predictive value and negative predictive value of hyperuricemia were 86.8% and 97.2% respectively. The overall diagnostic accuracy was 94.5%. Conclusion: Hyperuricemia in the first trimester is a reliable marker for prediction of gestational diabetes mellitus in later pregnancy.https://pafmj.org/index.php/PAFMJ/article/view/5577diagnostic accuracyfirst trimestergestational diabetes mellitushyperuricemiaoral glucose tolerance testuric acid
collection DOAJ
language English
format Article
sources DOAJ
author Aiza Rehman
Saima Qamar
Humaira Osman Jaffery
Uzma Asif
Faiza Ibrar
spellingShingle Aiza Rehman
Saima Qamar
Humaira Osman Jaffery
Uzma Asif
Faiza Ibrar
DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
Pakistan Armed Forces Medical Journal
diagnostic accuracy
first trimester
gestational diabetes mellitus
hyperuricemia
oral glucose tolerance test
uric acid
author_facet Aiza Rehman
Saima Qamar
Humaira Osman Jaffery
Uzma Asif
Faiza Ibrar
author_sort Aiza Rehman
title DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_short DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_full DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_fullStr DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_full_unstemmed DIAGNOSTIC ACCURACY OF FIRST TRIMESTER HYPERURICEMIA FOR PREDICTION OF GESTATIONAL DIABETES MELLITUS
title_sort diagnostic accuracy of first trimester hyperuricemia for prediction of gestational diabetes mellitus
publisher The Army Press
series Pakistan Armed Forces Medical Journal
issn 0030-9648
2411-8842
publishDate 2020-10-01
description Objective: To find the diagnostic accuracy of first trimester hyperuricemia for the prediction of development of subsequent gestational diabetes mellitus. Study Design: Cross-sectional study. Place and Duration of Study: Conducted at department of Obstetrics & Gynaecology, Combined Military Hospital Lahore, from Apr 2017 to Oct 2017. Methodology: All pregnant patients who met the inclusion criteria were enrolled in this study after informed consent. Blood samples in first trimester were collected for analysis of serum uric acid. Then after 24-28 weeks of gestation, Oral glucose tolerance test was done and presence of gestational diabetes mellitus was recorded. All the data were collected on a proforma. Results: The mean age of females was 26.70 ± 5.21 years. The mean height and weight was 1.62 ± 0.07 meters and 61.07 ± 8.54 kg respectively. Body mass index of patients was 23.32 ± 3.72 kg/m2. The mean gestational age of females was 9.96 ± 0.37 weeks at time of enrolment in the study. The mean uric acid level at time of presentation was 4.43 ± 3.61 mg/dl. In this study, the sensitivity and specificity of hyperuricemia for prediction of gestational diabetes mellitus were 91.1% and 95.7%. The positive predictive value and negative predictive value of hyperuricemia were 86.8% and 97.2% respectively. The overall diagnostic accuracy was 94.5%. Conclusion: Hyperuricemia in the first trimester is a reliable marker for prediction of gestational diabetes mellitus in later pregnancy.
topic diagnostic accuracy
first trimester
gestational diabetes mellitus
hyperuricemia
oral glucose tolerance test
uric acid
url https://pafmj.org/index.php/PAFMJ/article/view/5577
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AT humairaosmanjaffery diagnosticaccuracyoffirsttrimesterhyperuricemiaforpredictionofgestationaldiabetesmellitus
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