Lipoprotein-associated Phospholipase A2 is Associated with Angiographic Coronary Artery Disease and Coronary Artery Risk Factors in the Elderly

• Main Authors: Lini Dong, Xiaobing Qu, Zhi Gao Hu, Xiaoli Peng, Yanjiao Wang, Qin Miao, Xiangyu Zhang
• Format: Article
• Language: English
• Published: Taiwan Society of Geriatric Emergency and Critical Medicine (TSGECM) 2015-06-01
• Series: International Journal of Gerontology
• Subjects: C-reactive protein; coronary artery disease; elderly; high-sensitivity serum lipid; lipoprotein-associated phospholipase A2
• Online Access: http://www.sciencedirect.com/science/article/pii/S1873959815000368

Background: This study investigated the correlation of lipoprotein-associated phospholipase A2 (Lp-PLA2) levels with angiographic coronary artery disease, the extent of angiographic coronary artery lesions and coronary artery disease risk factors in the elderly. Methods: Plasma Lp-PLA2, lipid, and high-sensitivity C-reactive protein levels were measured in 192 elderly patients who underwent coronary angiography because of suspected coronary artery disease. The extent of coronary artery lesions was recorded according to the number of vessels with lesions and the Gensini score system. The relationships of Lp-PLA2 with angiographic coronary artery disease, the extent of coronary artery lesions, and associated risk factors were assessed. Results: Plasma Lp-PLA2 (359.56 ± 133.47 μg/L vs. 215.12 ± 58.93 μg/L, p < 0.001), triglycerides (1.87 ± 1.29mM vs. 1.23 ± 0.53mM, p < 0.001), total cholesterol (4.47 ± 0.69mM vs. 3.59 ± 0.75mM, p < 0.01), low-density lipoprotein cholesterol (2.52 ± 0.91mM vs. 2.10 ± 0.63mM, p < 0.01), and C-reactive protein (7.57 ± 1.82 mg/L vs. 2.65 ± 1.74 mg/L, p < 0.05) were significantly higher in the angiographic coronary artery disease group compared to the controls. Lp-PLA2 increased slightly but not significantly with an increasing number of coronary artery lesions and Gensini score. Spearman correlation analysis revealed that Lp-PLA2 is positively correlated with age (r = 0.249, p < 0.05), total cholesterol (r = 0.326, p < 0.01), and low-density lipoprotein cholesterol (r = 0.265, p < 0.05). Multivariate logistic regression analysis showed that Lp-PLA2 [odds ratio, 1.03 (1.01–1.06), p < 0.05] and total cholesterol [odds ratio, 2.74 (1.84–7.80), p < 0.05] are independent predictors for angiographic coronary artery disease. Conclusion: Lp-PLA2 was confirmed as a risk factor for coronary artery disease and independently predicts the presence of angiographic coronary artery disease in the elderly.