Brain region volumes and their relationship with disability progression and cognitive function in primary progressive multiple sclerosis

• Main Authors: Francisco Carlos Pérez‐Miralles, Daniel Prefasi, Antonio García‐Merino, José Ramón Ara, Guillermo Izquierdo, Virginia Meca‐Lallana, Francisco Gascón‐Giménez, María Luisa Martínez‐Ginés, Lluis Ramió‐Torrentà, Lucienne Costa‐Frossard, Óscar Fernández, Sara Moreno‐García, Jorge Maurino, Joan Carreres‐Polo, Bonaventura Casanova
• Format: Article
• Language: English
• Published: Wiley 2021-04-01
• Series: Brain and Behavior
• Subjects: brain volume; cognitive function; disability progression; magnetic resonance imaging; primary progressive multiple sclerosis
• Online Access: https://doi.org/10.1002/brb3.2044

Abstract Background and purpose Evidence on regional changes resulting from neurodegenerative processes underlying primary progressive multiple sclerosis (PPMS) is still limited. We assessed brain region volumes and their relationship with disability progression and cognitive function in PPMS patients. Methods This was an MRI analysis of 43 patients from the prospective Understanding Primary Progressive Multiple Sclerosis (UPPMS) cohort study. MRI scans were performed within 3 months before enrollment and at month 12. Results Gray matter volume of declive and white matter volumes adjacent to left straight gyrus, right calcarine sulcus, and right inferior occipital gyrus significantly decreased from baseline to month 12. Baseline white matter volumes adjacent to right amygdala and left cuneus significantly differed between patients with and without disability progression, as well as baseline gray matter volumes of left cuneus, right parahippocampal gyrus, right insula, left superior frontal gyrus, declive, right inferior temporal gyrus, right superior temporal gyrus (pole), and right calcarine sulcus. Baseline gray matter volumes of right cuneus and right superior temporal gyrus positively correlated with 12‐month Selective Reminding Test and Word List Generation performance, respectively. Gray matter changes in right superior semilunar lobe and white matter adjacent to left declive and right cerebellar tonsil also positively correlated with Word List Generation scores, while white matter change in left inferior semilunar lobe positively correlated with Symbol Digit Modalities Test performance after 12 months. Conclusions White and gray matter volumes of specific brain regions could predict disability progression and cognitive performance of PPMS patients after one year.