Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling
Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10873-y |
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doaj-1c54e7d3caaa498c865d65f8cebe16d42021-05-11T12:03:35ZengNature Publishing GroupNature Communications2041-17232019-07-0110111110.1038/s41467-019-10873-yUpper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signalingBrian D. Robinson0Panagiotis J. Vlachostergios1Bhavneet Bhinder2Weisi Liu3Kailyn Li4Tyler J. Moss5Rohan Bareja6Kyung Park7Peyman Tavassoli8Joanna Cyrta9Scott T. Tagawa10David M. Nanus11Himisha Beltran12Ana M. Molina13Francesca Khani14Juan Miguel Mosquera15Evanguelos Xylinas16Shahrokh F. Shariat17Douglas S. Scherr18Mark A. Rubin19Seth P. Lerner20Surena F. Matin21Olivier Elemento22Bishoy M. Faltas23Department of Pathology and Laboratory Medicine, Weill Cornell MedicineDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell MedicineDepartment of Physiology and Biophysics, Weill Cornell MedicineDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell MedicineDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell MedicineDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterDepartment of Physiology and Biophysics, Weill Cornell MedicineDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineDepartment of Urology, Weill Cornell MedicineDepartment of Urology, Weill Cornell MedicineDepartment of Urology, Weill Cornell MedicineDepartment of Urology, Weill Cornell MedicineDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineDepartment of Urology, Weill Cornell MedicineDepartment of Urology, Weill Cornell MedicineDepartment of Urology, Weill Cornell MedicineDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineScott Department of Urology, Baylor College of MedicineDepartment of Urology, The University of Texas MD Anderson Cancer CenterEnglander Institute for Precision Medicine, Weill Cornell MedicineEnglander Institute for Precision Medicine, Weill Cornell MedicineUpper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology.https://doi.org/10.1038/s41467-019-10873-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Brian D. Robinson Panagiotis J. Vlachostergios Bhavneet Bhinder Weisi Liu Kailyn Li Tyler J. Moss Rohan Bareja Kyung Park Peyman Tavassoli Joanna Cyrta Scott T. Tagawa David M. Nanus Himisha Beltran Ana M. Molina Francesca Khani Juan Miguel Mosquera Evanguelos Xylinas Shahrokh F. Shariat Douglas S. Scherr Mark A. Rubin Seth P. Lerner Surena F. Matin Olivier Elemento Bishoy M. Faltas |
| spellingShingle |
Brian D. Robinson Panagiotis J. Vlachostergios Bhavneet Bhinder Weisi Liu Kailyn Li Tyler J. Moss Rohan Bareja Kyung Park Peyman Tavassoli Joanna Cyrta Scott T. Tagawa David M. Nanus Himisha Beltran Ana M. Molina Francesca Khani Juan Miguel Mosquera Evanguelos Xylinas Shahrokh F. Shariat Douglas S. Scherr Mark A. Rubin Seth P. Lerner Surena F. Matin Olivier Elemento Bishoy M. Faltas Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling Nature Communications |
| author_facet |
Brian D. Robinson Panagiotis J. Vlachostergios Bhavneet Bhinder Weisi Liu Kailyn Li Tyler J. Moss Rohan Bareja Kyung Park Peyman Tavassoli Joanna Cyrta Scott T. Tagawa David M. Nanus Himisha Beltran Ana M. Molina Francesca Khani Juan Miguel Mosquera Evanguelos Xylinas Shahrokh F. Shariat Douglas S. Scherr Mark A. Rubin Seth P. Lerner Surena F. Matin Olivier Elemento Bishoy M. Faltas |
| author_sort |
Brian D. Robinson |
| title |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_short |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_full |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_fullStr |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_full_unstemmed |
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling |
| title_sort |
upper tract urothelial carcinoma has a luminal-papillary t-cell depleted contexture and activated fgfr3 signaling |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role of FGFR3 signaling in UTUC biology. |
| url |
https://doi.org/10.1038/s41467-019-10873-y |
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