Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications

Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications

We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic h...

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Main Authors: Krishna Adit Agarwal, Myat Han Soe
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2018/4038397
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spelling doaj-1c53b7dea9a1458bbbf9db9d1189a0362020-11-24T21:47:43ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/40383974038397Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future ImplicationsKrishna Adit Agarwal0Myat Han Soe1Department of Medicine, Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, USADepartment of Medicine, Baystate Medical Center, University of Massachusetts Medical School, Springfield, MA, USAWe present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC. In addition, we discuss neuroendocrine differentiation and ectopic hormone production in relation to intratumoral heterogeneity in SCLC and propose tumor microenvironment and hormonal and metabolic dependence as important determinants of tumor growth and survival.http://dx.doi.org/10.1155/2018/4038397
collection DOAJ
language English
format Article
sources DOAJ
author Krishna Adit Agarwal
Myat Han Soe
spellingShingle Krishna Adit Agarwal
Myat Han Soe
Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
Case Reports in Oncological Medicine
author_facet Krishna Adit Agarwal
Myat Han Soe
author_sort Krishna Adit Agarwal
title Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
title_short Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
title_full Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
title_fullStr Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
title_full_unstemmed Beyond the Dual Paraneoplastic Syndromes of Small-Cell Lung Cancer with ADH and ACTH Secretion: A Case Report with Literature Review and Future Implications
title_sort beyond the dual paraneoplastic syndromes of small-cell lung cancer with adh and acth secretion: a case report with literature review and future implications
publisher Hindawi Limited
series Case Reports in Oncological Medicine
issn 2090-6706
2090-6714
publishDate 2018-01-01
description We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) in which serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistant metabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss the diagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplastic endocrinopathies, and their prognostic impact on SCLC. In addition, we discuss neuroendocrine differentiation and ectopic hormone production in relation to intratumoral heterogeneity in SCLC and propose tumor microenvironment and hormonal and metabolic dependence as important determinants of tumor growth and survival.
url http://dx.doi.org/10.1155/2018/4038397
work_keys_str_mv AT krishnaaditagarwal beyondthedualparaneoplasticsyndromesofsmallcelllungcancerwithadhandacthsecretionacasereportwithliteraturereviewandfutureimplications
AT myathansoe beyondthedualparaneoplasticsyndromesofsmallcelllungcancerwithadhandacthsecretionacasereportwithliteraturereviewandfutureimplications
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