Guardian of Genetic Messenger-RNA-Binding Proteins
RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express a variety of RNA-binding proteins, which play...
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MDPI AG
2016-01-01
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| Series: | Biomolecules |
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| Online Access: | http://www.mdpi.com/2218-273X/6/1/4 |
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doaj-1c50575fc41443ae94ddb6c7cd6b09e72020-11-24T23:51:02ZengMDPI AGBiomolecules2218-273X2016-01-0161410.3390/biom6010004biom6010004Guardian of Genetic Messenger-RNA-Binding ProteinsAntje Anji0Meena Kumari1Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USADepartment of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USARNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express a variety of RNA-binding proteins, which play important roles in the pathologies of a number of diseases. In this review we focus on the effect of alcohol on different RNA-binding proteins and their possible contribution to alcohol-related disorders, and discuss the role of these proteins in the development of neurological diseases and cancer. We further discuss the conventional methods and newer techniques that are employed to identify RNA-binding proteins.http://www.mdpi.com/2218-273X/6/1/4RNA-binding proteinsmRNA stabilitymRNA splicinggene expressionalcoholneurological diseasescancer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Antje Anji Meena Kumari |
| spellingShingle |
Antje Anji Meena Kumari Guardian of Genetic Messenger-RNA-Binding Proteins Biomolecules RNA-binding proteins mRNA stability mRNA splicing gene expression alcohol neurological diseases cancer |
| author_facet |
Antje Anji Meena Kumari |
| author_sort |
Antje Anji |
| title |
Guardian of Genetic Messenger-RNA-Binding Proteins |
| title_short |
Guardian of Genetic Messenger-RNA-Binding Proteins |
| title_full |
Guardian of Genetic Messenger-RNA-Binding Proteins |
| title_fullStr |
Guardian of Genetic Messenger-RNA-Binding Proteins |
| title_full_unstemmed |
Guardian of Genetic Messenger-RNA-Binding Proteins |
| title_sort |
guardian of genetic messenger-rna-binding proteins |
| publisher |
MDPI AG |
| series |
Biomolecules |
| issn |
2218-273X |
| publishDate |
2016-01-01 |
| description |
RNA in cells is always associated with RNA-binding proteins that regulate all aspects of RNA metabolism including RNA splicing, export from the nucleus, RNA localization, mRNA turn-over as well as translation. Given their diverse functions, cells express a variety of RNA-binding proteins, which play important roles in the pathologies of a number of diseases. In this review we focus on the effect of alcohol on different RNA-binding proteins and their possible contribution to alcohol-related disorders, and discuss the role of these proteins in the development of neurological diseases and cancer. We further discuss the conventional methods and newer techniques that are employed to identify RNA-binding proteins. |
| topic |
RNA-binding proteins mRNA stability mRNA splicing gene expression alcohol neurological diseases cancer |
| url |
http://www.mdpi.com/2218-273X/6/1/4 |
| work_keys_str_mv |
AT antjeanji guardianofgeneticmessengerrnabindingproteins AT meenakumari guardianofgeneticmessengerrnabindingproteins |
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1725477819160461312 |