<i>CYP2D6</i> Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites in Ethiopian Breast Cancer Patients

<i>CYP2D6</i> Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites in Ethiopian Breast Cancer Patients

Tamoxifen displays wide inter-individual variability (IIV) in its pharmacokinetics and treatment outcome. Data on tamoxifen pharmacokinetics and pharmacogenetics from black African breast cancer patient populations is lacking. We investigated the pharmacokinetic and pharmacogenetic profile of tamoxi...

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Bibliographic Details
Main Authors: Jemal Hussien Ahmed, Eyasu Makonnen, Alan Fotoohi, Abraham Aseffa, Rawleigh Howe, Eleni Aklillu
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
tamoxifen
endoxifen
pharmacokinetics
pharmacogenetics
<i>CYP2D6</i>
<i>ABCB1</i>
breast cancer
Online Access:https://www.mdpi.com/2072-6694/11/9/1353

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