The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease (AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene expression is regulated in a region-specific manner over the course of normal aging and in neurodegenerative disease...

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Bibliographic Details
Main Authors:	Luke W. Bonham, Daniel W. Sirkis, Jennifer S. Yokoyama
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-06-01
Series:	Frontiers in Immunology
Subjects:	microglia Alzheimer's disease genetics TMEM119 cell-type profiling frontotemporal dementia
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01170/full

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