A novel three-filament model of force generation in eccentric contraction of skeletal muscles.

A novel three-filament model of force generation in eccentric contraction of skeletal muscles.

We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of...

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Main Authors: Gudrun Schappacher-Tilp, Timothy Leonard, Gertrud Desch, Walter Herzog
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0117634
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spelling doaj-1c38e2dc77d947dfb5a6215e5f8dc66c2021-03-03T20:07:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011763410.1371/journal.pone.0117634A novel three-filament model of force generation in eccentric contraction of skeletal muscles.Gudrun Schappacher-TilpTimothy LeonardGertrud DeschWalter HerzogWe propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.https://doi.org/10.1371/journal.pone.0117634
collection DOAJ
language English
format Article
sources DOAJ
author Gudrun Schappacher-Tilp
Timothy Leonard
Gertrud Desch
Walter Herzog
spellingShingle Gudrun Schappacher-Tilp
Timothy Leonard
Gertrud Desch
Walter Herzog
A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
PLoS ONE
author_facet Gudrun Schappacher-Tilp
Timothy Leonard
Gertrud Desch
Walter Herzog
author_sort Gudrun Schappacher-Tilp
title A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
title_short A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
title_full A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
title_fullStr A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
title_full_unstemmed A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
title_sort novel three-filament model of force generation in eccentric contraction of skeletal muscles.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2015-01-01
description We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.
url https://doi.org/10.1371/journal.pone.0117634
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