A DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL ON THE EFFECT OF FLAXSEED AND OLIVE OILS ON CONSTIPATION OF HEMODIALYSIS PATIENTS: PRELIMINARY RESULTS.

• Main Authors: Christiane I. Ramos, Aline F.A. de Lima, Daniela G. Grilli, Giovana Sertori, Maria A. Kamimura, Lilian Cuppari
• Format: Article
• Language: English
• Published: The Korean Society of Nephrology 2012-06-01
• Series: Kidney Research and Clinical Practice
• Online Access: http://www.sciencedirect.com/science/article/pii/S2211913212006432

Mineral oil has been used in the treatment of constipation in hemodialysis patients. Edible oils could also be a good option for treating this symptom. Therefore we aimed to investigate the effect of flaxseed and olive oils on constipation of hemodialysis patients. This trial was conducted for 4 weeks. Constipation was diagnosed by Rome III criterion. Thirty six constipated patients (18M, 51.0±12.2 years) were randomized into Mineral oil (MG; n=11), Flaxseed oil (FG; n=11) and Olive oil (OG; n=14) groups. The initial dose of each oil was 4 ml/d and was adjusted as needed. There was no difference in total oil used among groups (150.7±43.7 ml, 165.8±53.3 ml, 144.4±49.5 ml, respectively; p=0.61). The prevalence of each Roma III criterion item was similar among the groups. MG (%) OG (%) FG (%) 0 wk4 0 wk4 0 wk4 Abdominal pain 54.5 27.3 36.4 9.1* 9.1 0 Straining on defecation 30.8 7.7 34.6 11.5* 34.6 15.4 Lumpy or hard stools 32.3 9.7 39.7 12.9 29.0 12.9 Incomplete evacuation 28.1 18.8 43.8 28.1 28.1 18.8 Anorectal obstruction 29.2 12.5 45.8 4.2* 25.0 12.5 Manual maneuvers 25.0 0 50.0 0* 25.0 0 < 3 evacuation/week 36.8 5.3* 31.6 10.5* 31.6 15.8 This preliminary result suggests that olive oil could be a healthy alternative on treatment of constipation in hemodialysis patients. ⁎ p<0.05; 0 vs wk4.