The Effect of Oxidized Dopamine on the Structure and Molecular Chaperone Function of the Small Heat-Shock Proteins, αB-Crystallin and Hsp27

The Effect of Oxidized Dopamine on the Structure and Molecular Chaperone Function of the Small Heat-Shock Proteins, αB-Crystallin and Hsp27

Oxidation of the neurotransmitter, dopamine (DA), is a pathological hallmark of Parkinson’s disease (PD). Oxidized DA forms adducts with proteins which can alter their functionality. αB-crystallin and Hsp27 are intracellular, small heat-shock molecular chaperone proteins (sHsps) which form the first...

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Bibliographic Details
Main Authors: Junna Hayashi, Jennifer Ton, Sparsh Negi, Daniel E. K. M. Stephens, Dean L. Pountney, Thomas Preiss, John A. Carver
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
small heat-shock protein
αB-crystallin
Hsp27
molecular chaperone
Parkinson’s disease
dopamine
Online Access:https://www.mdpi.com/1422-0067/22/7/3700

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https://www.mdpi.com/1422-0067/22/7/3700

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