Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Abstract.: We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-expos...

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Main Authors: Takanori Akagi, Yuta Matsumura, Masaya Yasui, Emiko Minami, Hidemasa Inoue, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Kazue Mizumura, Makoto Tsuda, Hiroshi Kiyama, Kazuhide Inoue
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319300660
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spelling doaj-1c28122e70aa499a85212b802f8817e22020-11-24T21:49:18ZengElsevierJournal of Pharmacological Sciences1347-86132014-01-011262172176Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in RodentsTakanori Akagi0Yuta Matsumura1Masaya Yasui2Emiko Minami3Hidemasa Inoue4Takahiro Masuda5Hidetoshi Tozaki-Saitoh6Tomohiko Tamura7Kazue Mizumura8Makoto Tsuda9Hiroshi Kiyama10Kazuhide Inoue11Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, JapanDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, JapanDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showaku, Nagoya 446-8550, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, JapanDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, JapanDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, JapanDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, JapanDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, JapanDepartment of Immunology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, JapanDepartment of Physical Therapy, College of Life and Health Sciences, Chubu University, Kasugai, JapanDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, JapanDepartment of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showaku, Nagoya 446-8550, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, JapanDepartment of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka 812-8582, Japan; Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, Japan; Corresponding author. inoue@phar.kyushu-u.ac.jpAbstract.: We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure. Keywords:: interferon regulatory factor-8, microglia, repeated cold stresshttp://www.sciencedirect.com/science/article/pii/S1347861319300660
collection DOAJ
language English
format Article
sources DOAJ
author Takanori Akagi
Yuta Matsumura
Masaya Yasui
Emiko Minami
Hidemasa Inoue
Takahiro Masuda
Hidetoshi Tozaki-Saitoh
Tomohiko Tamura
Kazue Mizumura
Makoto Tsuda
Hiroshi Kiyama
Kazuhide Inoue
spellingShingle Takanori Akagi
Yuta Matsumura
Masaya Yasui
Emiko Minami
Hidemasa Inoue
Takahiro Masuda
Hidetoshi Tozaki-Saitoh
Tomohiko Tamura
Kazue Mizumura
Makoto Tsuda
Hiroshi Kiyama
Kazuhide Inoue
Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents
Journal of Pharmacological Sciences
author_facet Takanori Akagi
Yuta Matsumura
Masaya Yasui
Emiko Minami
Hidemasa Inoue
Takahiro Masuda
Hidetoshi Tozaki-Saitoh
Tomohiko Tamura
Kazue Mizumura
Makoto Tsuda
Hiroshi Kiyama
Kazuhide Inoue
author_sort Takanori Akagi
title Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents
title_short Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents
title_full Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents
title_fullStr Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents
title_full_unstemmed Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents
title_sort interferon regulatory factor 8 expressed in microglia contributes to tactile allodynia induced by repeated cold stress in rodents
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2014-01-01
description Abstract.: We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure. Keywords:: interferon regulatory factor-8, microglia, repeated cold stress
url http://www.sciencedirect.com/science/article/pii/S1347861319300660
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