Progressive effect of beta amyloid peptides accumulation on CA1 pyramidal neurons: a model study suggesting possible treatments

Progressive effect of beta amyloid peptides accumulation on CA1 pyramidal neurons: a model study suggesting possible treatments

Several independent studies show that accumulation of β-amyloid (Aβ) peptides , one of the characteristic hallmark of Alzheimer’s Disease (AD), can affect normal neuronal activity in different ways. However, in spite of intense experimental work to explain the possible underlying mechanisms of acti...

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Bibliographic Details
Main Authors:	Viviana eCulmone, Michele eMigliore
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2012-07-01
Series:	Frontiers in Computational Neuroscience
Subjects:	Alzheimer's disease Aβ-peptide hippocampal neuron ion channels modulation realistic model
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00052/full

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