Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease

Inflammatory and Infectious Processes Serve as Links between Atrial Fibrillation and Alzheimer’s Disease

Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanism...

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Bibliographic Details
Main Authors: Gabriela Lopes Martins, Rita Carolina Figueiredo Duarte, Marat A. Mukhamedyarov, András Palotás, Cláudia Natália Ferreira, Helton José Reis
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
anti-inflammatory therapy
arrhythmia
atrial fibrillation
dementia
endothelial damage
Online Access:https://www.mdpi.com/1422-0067/21/9/3226
Description
Summary:Atrial fibrillation (AF) is one of the most prevalent forms of arrhythmia that carries an increased risk of stroke which, in turn, is strongly associated with cognitive decline. The majority of dementia cases are caused by Alzheimer’s disease (AD) with obscure pathogenesis. While the exact mechanisms are unknown, the role of inflammatory processes and infectious agents have recently been implicated in both AD and AF, suggesting a common link between these maladies. Here, we present the main shared pathways underlying arrhythmia and memory loss. The overlapping predictive biomarkers and emerging joint pharmacological approaches are also discussed.
ISSN:1661-6596
1422-0067

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